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KMID : 0545119910010030163
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Journal of Microbiology and Biotechnology
1991 Volume.1 No. 3 p.163 ~ p.168
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A New Potent Angiogenesis Inhibitor, FR-118487
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TAKANAO, OTSUKA
OHKAWA, TAKEHIKO/SHIBATA, TOSHIHIRO/OKU, TERUO/OKUHARA, MASAKUNI/TERANO, HIROSHI/MASANOBU KOHSAKA
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Abstract
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A new angiogenesis inhibitor, FR-118487 was obtained by chemical modification of FR-111142 which was isolated from the fermentation products of Scolecobasidium arenarium F-2015. The antiangiogenic activity of FR-118487 was compared with that of the parent compound, FR-111142. In the endothelial cell proliferation test in vitro and the anglogenesis in the chick embryo chorioallantoic membrane assay, FR-118487 had about 5∼10 times stronger antiangiogenic activities than FR-111142. In addition, FR-118487 inhibited the angiogenesis in the rabbit corneal assay and suppressed the solid tumor growth in mice. These findings showed that FR-118487 would be a unique antiangiogenic agent with promising antitumor activity.
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KEYWORD
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